科创中国

Safety, tolerability and satisfaction with tegaserod therapy in Asia-Pacific patients with irritable bowel syndrome with constipation

• 摘要：

  Background and Aim: The 5-HT₄receptor agonist tegaserod (6 mg b.i.d.) provides significantly better overall multiple symptom relief compared with placebo in patients with irritable bowel syndrome with constipation (IBS-C). The clinical benefit and safety of tegaserod in IBS-C patients has been demonstrated worldwide in several studies. The aim of this study was to obtain further safety and tolerability data in patients with IBS in the Asia-Pacific region, and to assess patients' satisfaction and compliance with treatment and willingness to re-use tegaserod in a post-marketing setting. Methods: A multicenter, single-arm, open-label trial was conducted at 869 outpatient centers in 10 countries. Men and women with IBS, whose predominant bowel symptom was not diarrhea (non-D-IBS), received tegaserod for 4-12 weeks. Safety and tolerability were assessed by recording adverse events (AE). Patients were questioned about compliance, satisfaction with treatment and willingness to use tegaserod in future. Results: Data were available from 14 537 patients (18% men, 82% women). Four percent of patients reported at least one AE. The most common AE were diarrhea (2%) and abdominal pain (1%), and most treatment-related AE occurred in the first week of treatment. Serious AE (SAE) were observed in eight patients, and no deaths were reported. Most patients (79%) reported to be satisfied or very satisfied with treatment, and 76% stated they would use tegaserod in the future. Compliance was 97%. Conclusions: Tegaserod has a favorable safety and tolerability profile for treating non-D-IBS and IBS-C in men and women in the Asia-Pacific region. Satisfaction with tegaserod treatment can be expected in the majority of patients.

• 作者：

  Kwong M. Fock;Amy Wagner;M. A. Ahad;D. S. Ahmed;F. Ahmed;M. M. Ahmed;M. S. Ali;M. R. Bhuiyan;D. Chowdhury;M. Hasan;S. M. Ishaqe;A. Kabir;M. R. Khan;H. Masud;M. A. Masud;M. A. Rab Sarkar;M. A. Rahim Mia;M. H. Rahman;A. S.M.A. Raihan;A. H.M. Rowsan;P. K. Roy;S. K. Saha;W. Y. Bai;J. T. Cai;B. Cao;X. M. Chang;J. F. Chen;J. X. Chen;J. Y. Chen;L. D. Chen;L. J. Chen;M. X. Chen;W. C. Chen;W. X. Chen;X. M. Chen;Y. Chen;Y. L. Chen;Y. S. Chen;J. X. Cheng;X. Y. Cui;M. M. Deng;Y. J. Ding;J. D. Dong;L. Dong;S. X. Dong;G. P. Du;L. P. Duan;代明 樊;Z. J. Fan;D. C. Fang;H. Feng;K. Feng;Y. K. Feng;Z. T. Feng;B. Y. Fu;J. Fu;A. H. Gan;X. Y. Gao;X. Z. Gao;F. L. Gong;F. Y. Gong;L. Gong;G. M. Gu;X. H. Gu;H. X. Guo;X. Z. Guo;Y. M. Guo;L. Q.M. Hai;R. G. Han;S. X. Han;Z. Han;Y. Hong;J. R. Hou;X. H. Hou;Y. Hu;Z. K. Hu;D. W. Hua;G. M. Huang;H. Huang;J. F. Huang;K. M. Huang;L. Y. Huang;S. P. Huang;X. F. Huang;Y. M. Huang;Z. J. Huang;L. J. Huo;F. Ji;Z. Z. Ji;L. P. Jia;F. H. Jian;Y. B. Jiang;Z. C. Kan;B. Li;B. J. Li;D. G. Li;F. K. Li;F. R. Li;J. J. Li;J. S. Li;N. Li;R. Z. Li;S. D. Li;S. L. Li;Y. Li;Y. M. Li;Y. Q. Li;P. X. Liang;M. Lin;W. Lin;F. Liu;H. L. Liu;J. Y. Liu;N. Z. Liu;Q. Liu;Q. Y. Liu;S. Y. Liu;W. Z. Liu;X. G. Liu;X. H. Liu;X. M. Liu;Y. L. Liu;Z. W. Liu;J. Y. Lu;Q. Lu;S. Y. Lu;X. P. Lu;Z. P. Lu;H. S. Luo;Z. J. Luo;B. Lu;N. H. Lu;J. Ma;X. D. Ma;X. Z. Meng;Y. Q. Nie;Y. Q. Ou;X. B. Peng;Y. F. Piao;S. M. Qi;C. H. Qiao;J. L. Ren;X. Ren;B. B. Shen;S. R. Shen;W. Shen;W. Z. Shen;Y. Z. Shen;S. H. Shi;F. Shu;Y. L. Si;S. H. Song;J. C. Sui;C. Sun;G. H. Sun;S. Q. Sun;Z. B. Tian;B. Wang;B. J. Wang;B. M. Wang;C. D. Wang;F. Y. Wang;G. S. Wang;J. B. Wang;J. G. Wang;M. Wang;M. Y. Wang;Q. Wang;Q. Wang;Q. M. Wang;Q. Y. Wang;S. F. Wang;S. X. Wang;X. Q. Wang;X. Z. Wang;Y. D. Wang;Z. F. Wang;L. Wei;L. Wei;Z. F. Wen;G. Wu;H. Wu;J. Wu;P. Wu;Q. Wu;Q. M. Wu;W. Wu;W. D. Wu;H. Z. Xia;M. Xie;W. F. Xie;C. H. Xu;H. L. Xu;J. M. Xu;L. Xu;L. G. Xu;Y. G. Xu;Z. Xu;H. J. Yan;G. M. Yang;N. Yang;Y. L. Yang;Y. S. Yang;Y. X. Yang;H. C. Yao;H. J. Ye;Y. A. Ye;C. M. Yu;J. J. Yu;J. X. Yu;X. M. Yu;Y. Z. Yuan;X. Z. Zeng;B. X. Zhang;C. Q. Zhang;C. Y. Zhang;G. Y. Zhang;L. Zhang;R. H. Zhang;R. X. Zhang;S. S. Zhang;S. T. Zhang;T. C. Zhang;W. Q. Zhang;X. Zhang;X. P. Zhang;Z. G. Zhang;Z. J. Zhang;B. Zhao;C. X. Zhao;H. C. Zhao;Y. H. Zhao;Y. X. Zhao;Z. Q. Zhao;J. H. Zhen;J. J. Zheng;J. W. Zheng;L. Zheng;S. H. Zheng;W. H. Zheng;C. L. Zhou;H. X. Zhou;L. Zhou;L. Y. Zhou;M. Z. Zhou;N. F. Zhou;P. Z. Zhou;S. D. Zhou;Z. L. Zhou;F. L. Zhu;H. H. Zhu;H. M. Zhu;L. M. Zhu;R. M. Zhu;W. Zhu;X. L. Zhu;Y. Q. Zhu;Z. H. Zhu;Z. Y. Zhu;E. T. Chan;K. C. Chan;K. D.K. Chan;C. C. Chang;P. K. Cheng;C. S. Cheung;K. P. Fung;R. B. Heath;L. S.C. Hooi;W. J. Hu;W. L. Hui;P. S. Ip;K. C. Lam;D. K.K. Leung;Y. K. Leung;C. H. Lo;R. Lo;M. T. Lui;S. W.L. Luk;A. C.W. Mui;K. K. Ng;W. C. Ng;C. O. Pong;O. S. Poon;R. K.W. Tang;C. A. Tsang;K. H. Tsang;C. G. Tsui;C. S. Wong;J. Wong;T. C. Wong;R. K.H. Yau;W. H. Yau;F. Y.K. Yu;K. C. Yu;W. H. Yu;G. K. Abadi;B. Y. Anwar;H. F. Arifin;G. Arsyadi;S. Ashar;A. F. Bakry;H. Basri;Y. Chandra;L. Choandry;T. R. Damanik;T. Daryatmo;T. S. Denny;A. Dharmawan;G. Dibjojuwono;L. K. Djimesha;I. Effendi; Indriyanto; Komariatun;A. Kristanto;S. Leonardi;S. Makmun;S. Marpaung;A. Masidin;E. Merentek;K. Nazar;T. Ongko;W. Permadi;M. S. Pranantyo;H. Purbayu;A. Rahimi;A. Rasjid;Q. Rijono;Z. Said;P. B. Santoso;A. Setiadarma;S. Setiadji;H. Setiady;I. Setyopranantyo;H. Sidhojoyo;C. Sjah;R. Sitompul;J. Soedjono;N. Soemargo;F. X.T. Soetjahjo;L. Soetjipto;H. R. Surasmo;F. Suriadi;H. Suryadi;H. Susatyo;A. F. Syam;L. S. Tanudjaja;A. Taslam;L. Taufik;N. Tjahjo;W. Tjandra;G. Tjora;E. W. Walujan;U. Wibowo;I. Wijaya;A. Wirawan;G. Wirotomo;A. Yudiono;W. Zaenudin; Zainab;H. Y. A;J. K. Ahn;K. H. Ahn;T. W. Ahn;H. C. An;L. S. An;S. S. Bae;Y. G. Bae;J. C. Baek;J. G. Baek;K. R. Chae;S. D. Chai;D. H. Chang;H. W. Chang;W. K. Chang;S. R. Cheon;J. K. Cho;J. S. Cho;K. S. Cho;M. N. Choe;B. C. Choi;H. S. Choi;J. Choi;J. P. Choi;J. S. Choi;K. H. Choi;K. S. Choi;M. S. Choi;W. S. Choi;Y. S. Choi;C. W. Chun;W. S. Chung;H. Y. Eo;J. H. Eun;W. K. Go;H. Y. Ha;B. S. Han;K. I. Han;S. H. Han;S. T. Han;S. W. Han;S. C. Hong;S. M. Hong;E. W. Hwang;J. H. Hwang;J. Y. Hwang;K. K. Hwang;S. H. Hwang;C. H. Jang;D. I. Jang;J. Jang;S. J. Jang;M. H. Jeon;S. K. Jeon;S. D. Jeong;S. B. Jin;Y. J. Jin;Y. H. Joo;E. G. Journ;H. J. Ju;J. S. Ju;B. Y. Jung;D. W. Jung;H. J. Jung;H. S. Jung;K. H. Jung;Y. H. Jung;Y. S. Jung;Y. C. Jyeong;H. A. Kang;J. S. Kang;J. W. Kang;M. S. Kang;P. J. Kang;S. W. Kang;S. M. Keum;A. K. Kim;B. R. Kim;B. S. Kim;C. S. Kim;D. H. Kim;D. H. Kim;D. S. Kim;D. Y. Kim;E. C. Kim;G. H. Kim;G. H. Kim;G. W. Kim;H. B. Kim;H. H. Kim;H. W. Kim;J. B. Kim;J. C. Kim;J. H. Kim;J. H. Kim;J. H. Kim;J. H. Kim;J. I. Kim;J. M. Kim;J. S. Kim;J. S. Kim;J. W. Kim;J. Y. Kim;J. Y. Kim;J. Y. Kim;K. J. Kim;K. W. Kim;M. R. Kim;S. E. Kim;S. S. Kim;S. T. Kim;T. Y. Kim;W. D. Kim;W. S. Kim;Y. G. Kim;Y. H. Kim;Y. J. Kim;Y. S. Kim;Y. T. Kim;Y. W. Kim;B. G. Ko;S. P. Kook;O. S. Kwon;N. K. Kwun;B. D. Lee;B. G. Lee;B. J. Lee;B. W. Lee;C. W. Lee;G. J. Lee;G. T. Lee;H. Lee;H. J. Lee;H. M. Lee;H. Y. Lee;J. I. Lee;J. N. Lee;J. W. Lee;J. Y. Lee;K. R. Lee;K. S. Lee;M. B. Lee;M. S. Lee;P. K. Lee;S. B. Lee;S. C. Lee;S. H. Lee;S. J. Lee;S. M. Lee;S. W. Lee;S. W. Lee;W. S. Lee;Y. B. Lee;Y. W. Lee;H. K. Lim;J. H. Lim;W. S. Lim;D. K. Lo;C. S. Moon;D. S. Moon;S. I. Moon;S. H. Na;B. H. Nam;G. H. Nam;L. H. Nam;S. Y. O;H. S. Oh;H. S. Oh;S. H. Oh;S. H. Oh;S. H. Oh;G. T. Park;H. C. Park;H. J. Park;J. H. Park;J. J. Park;J. N. Park;J. Y. Park;K. H. Park;K. T. Park;S. G. Park;S. H. Park;T. R. Park;Y. H. Park;Y. I. Park;Y. J. Park;Y. S. Park;H. S. Rhim;Y. H. Rho;S. K. Ro;S. K. Roh;T. S. Roh;S. K. Ryu;J. S. Ryue;J. H. Shim;H. W. Shin;J. C. Shin;J. H. Shin;K. S. Shin;K. S. Shin;N. C. Shin;S. T. Shin;Y. Shin;D. H. Shon;J. H. Sohn;K. S. Sohn;S. H. Sohn;H. B. Son;T. Y. Son;C. W. Song;H. Y. Song;I. K. Song;J. S. Song;K. H. Song;K. H. Song;K. J. Song;H. R. Suh;D. J. Sung;M. S. Sung;J. Y. Tack;W. H. Won;K. E. Woo;J. Y. Woo;D. H. Yang;H. H. Yang;J. S. Yang;J. Y. Yang;S. W. Yang;S. W. Yang;J. Y. Yeo;K. Y. Yeom;H. S. Yim;K. B. Yim;J. S. Yoo;Y. K. Yoo;C. K. Yoon;D. H. Yoon;J. G. Yoon;J. Y. Yoon;Y. K. Yoon;Y. S. Yoon;C. M. Youk;Y. H. Youn;B. J. Yu;K. H. Yu;S. J. Yun;U. D. Yun;A. Ahmad; Bahari.S;K. Chandran;W. S. Chen;Y. C. Chia; Davaraj;S. Doshi;P. S. Gill;A. Gunn;M. R.A. Hassan;S. Huang;S. Jacob;H. M. Liau;P. Y. Lu; Manohari;J. Menon;K. T. Ong;E. K. Ooi;R. Ponnudurai;G. Salleho;A. Shukri;L. K. Tan;I. Acusar;M. Adraneda;B. Agbay;F. Aguas;W. Alba;A. Aldon;S. Alegarbes;L. Alves;V. Ang;M. Aquino;M. Arguillas;M. Atienza;Q. Babaran;R. Babaran;R. Bagsic;R. Balmaceda;D. Banayo;A. Bansil;I. Baquiran Masa;M. Basco;J. Bautista;B. Benitez;J. Bocobo;E. Bondoc;C. Bruel;M. Bunyi;R. Caballero;J. Caluag;J. Campos;L. Carandang;R. Carpio;A. Ceniza;J. Cervantes;C. Chan;M. Chan;A. Chua;A. M. Chua;F. Chua;A. Co;A. Comia;J. CoSoriano;O. Cruz;C. Dado-Dalupang;L. Daez;C. De Castro;J. Demyttenaere;N. Dizon;F. Domingo;G. Duque;E. Dy;M. Einanloo;A. Elevazo;D. Encarnacion;P. Eng Lim;D. Entera;A. Espiritu;A. Esteras;E. Flores;A. Frias;E. Gabriel;A. Galang;C. Gallinera;E. Gambe;T. Gamutan;J. Gapasin;G. Gaw;B. Gonzales;D. Gonzales;R. Gonzales;J. M. Guzman;J. Ignacio;A. Ismael;A. Jimenez;R. Kiok Go;A. Kuan;R. Lacson;R. Lacuesta;J. Lao-Tan;J. Ledesma;C. P. Lim;E. Lim;V. Lim;V. Lo;R. Lobaton;R. Lopez;J. R. Lubag;N. Lucido;M. Lustre;J. Macaraeg;R. Magdaong;L. Manabat;W. Manuela;G. Marquez;R. Mercado;R. Miranda;J. Moreno;B. Moscoso;T. Nadala;R. Naval;D. Ngo;E. Olympia;D. Ona;E. Ong;H. Ong;L. Ong;M. Ortiz;V. Paez;R. Palaganas;M. Pamaylaon;J. Pangilinan;D. Parungao;D. Payawal;D. Peña;G. Perlas;J. Pio Reyes;A. Policarpio;E. Portigo;S. Querubin-De Ocampo;J. L. Ramos;P. Retusto;V. Revelo;A. Reyes;C. Reyes;E. Ricarte;N. Rico;A. Ruiz;C. Salazar-Tady;L. Salvador;R. Santi;J. Sollano;M. Sotomil;A. Sta. Ana;C. Sy;R. Tambuyat;J. Tan;G. Tecson;A. M. Tolentino;C. Torio;R. Umil;A. Uy;D. Valencia;V. Valencia;R. Vallar;R. Venezuela;L. C. Vicerra;T. Villa;G. Villanueva;A. Vitug;R. Yap;R. Ycong;G. Ypil;A. Zablan;F. Zaño;P. K. Ang;S. H. Cheng;D. Eu;P. Goh;K. A. Gwee;S. M. Heah;L. Ho;P. Ho;W. W. Hu;S. M. Kong;P. L. Kwak;G. Kwan;C. G. Leow;C. C. Lim;G. L. Lim;C. Loo;H. F. Lui;M. H. Ng;D. Nyam;K. B. Siah;H. H. Tan;S. T. Tan;Y. T. Tan;M. L. Wong;C. C. Chang;C. S. Chang;P. C. Chen;C. H. Chu;S. K. Chuah;W. C. Ho;C. Y. Huang;A. W. Kao;C. H. Kuo;C. H. Kuo;C. C. Lin;J. H. Liu;C. C. Lo;G. H. Lo;M. Y. Su;Y. C. Su;K. M. Tam;H. H. Wang;W. M. Wang;D. C. Wu;F. J. Yu;J. Amornrattanakosol;K. Angkananupong;V. Ariyawongsopon;R. Boonsirichan;V. Cahmchuklin;W. Chaiphornphothana;V. Chantarasuntinkul;C. Chaoprasong;B. Chareonsil;P. Charuscharoenwitt-haya;D. Chokmongkolkij;V. Chomsaksakul;P. Chualwiwat;Y. Dhapasita;S. Gonlachanvit;N. Issariyakullkran;K. Jankiatfoo;D. Janthayanont;P. Kengchon;U. Kiatpanabrikul;P. Kobklachaiyapong;A. Konchome;C. Koosirirat;V. Kositsakulchai;S. Kuslasiyanon;B. Lecksiwlai;S. Lee;K. Mahapol;P. Manosithisak;K. Memonkolkulldilok;S. Mungkorn;D. Noothongkam;T. Noungkunsan;Y. Osothtanakorn;W. Pasurapanya;E. Pethplook;A. Ploodi;T. Pongnakine;S. Prasertsuk;C. Saengborisuit;T. Sanchai;W. Sanpanich;K. Sarakune;E. Singhatiraj;S. Sirinthornpunya;W. Srisukchalarn;P. Sueyunyongsiri;J. Sukchai;P. Tansenee;K. Thhikul;T. Tongbai;P. Trongritthichaikan;W. Uthaisaengsook;A. Vasuwat;R. Vilaichom;V. Vimolchalao;P. Virajsilp;P. Wongtagual;N. Wuttidechkamjorn;C. Yamcharoen;P. Yimchalarn;J. Yossombat

• 刊名：

  Journal of Gastroenterology and Hepatology (Australia)

• 在线出版时间：

  2007-8-1