科创中国

Association of H. pylori infection with gastric carcinoma: A meta analysis

• 摘要：

  Aim: To follow the principles of evidence based medicine to reach the integrated results of these studies. Methods: Twenty-one papers of case-control studies were selected, including 11 on gastric cancer, 7 on precancerous lesion of stomach and 3 on lymphoma of stomach. Meta analysis was used to sum up the odds ratios (OR) of these studies. Results: H. pylori vs gastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016 (95% Cl: 2.4197-3.7234, P < 0.001). H. pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% Cl: 1.8477-3.5566, P < 0.01). H. pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. pylori infections. Conclusion: Since it had been revealed that H. pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. pylori infection is a risk factor for gastric carcinoma.

• 作者：

  Xue F. B.;Xu Y. Y.;Wan Y.;Pan B. R.;Ren J.;Fan D. M.

• 刊名：

  World Journal of Gastroenterology

• 在线出版时间：

  2001