您所在的位置: 成果库 邻苯二酚基改性生物大分子支架材料及其制备方法

邻苯二酚基改性生物大分子支架材料及其制备方法

发布时间: 2022-04-01

基本信息

合作方式： 技术转让
成果类型： 发明专利
行业领域：
其他
成果介绍
  • ***, oxidized polymerization, and adhesion of dopamine to prepare and obtain the catechol group modified biomacromolecular scaffold material with a compound containing the catechol group.
  • ***, a compound containing catechol groups and biomacromolecules is subjected to amidation to prepare and obtain biomacromolecules with excellent adhesion; then, the dopamine performs self-polymerization in an aqueous solution of ammonia to generate polydopamine particles which are uniform in particle size; next, a scaffold which has three cross-linking structures, namely modified biomacromolecules, modified biomacromolecules/polydopamine, and biomacromolecules/polydopamine, is formed through interaction between catechol groups, interaction between catechol groups and polydopamine particles, and interaction between macromolecules and polydopamine particles in the modified macromolecules respectively; and finally, calcium ions are cross-linked with the scaffold to obtain a gradient scaffold material.
  • ***, hyaluronic acid, polyglutamic acid, chitosan, and polylysine.
  • ***, hyaluronic acid or polyglutamic acid, the compound containing the catechol group is dopamine; and when biomacromolecules are chitosan or polylysine, the compound containing the catechol group is 3,4-dihydroxyphenylpropionic acid.
  • ***-1:5, and the degree of substitution of the catechol group in the biomolecules is within the range of 16-60%.
  • ***, the amount of ammonia water is within the range of *** mL, and the particle size of the obtained polydopamine particles is within the range of 150-560 nm.
  • ***-pure water are 4%, and the concentration of the polydopamine particles is ***%.
  • ***%.
  • ***-91%.
  • *** *** biomacromolecules and a compound containing catechol groups to perform amidation to prepare and obtain catechol group modified biomacromolecules;freeze-drying the catechol group modified biomacromolecules to obtain a catechol group modified biomacromolecular material; or mixing the catechol group modified biomacromolecules with polydopamine, then freeze-drying the mixture of the catechol group modified biomacromolecules and polydopamine to obtain a catechol group modified biomacromolecules/polydopamine compound material; andcross-linking the freeze-dried catechol group modified biomacromolecular material or the catechol group modified biomacromolecules/polydopamine compound material by using a cross-linking agent to obtain a catechol group modified biomacromolecular compound scaffold material; or,*** biomacromolecules with polydopamine, then freeze-drying the mixture of the biomacromolecules and polydopamine to obtain a biomacromolecules/polydopamine compound material; andcross-linking the freeze-dried biomacromolecules/polydopamine compound material by using a cross-linking agent to obtain the catechol group modified biomacromolecular scaffold material.
  • ***, hyaluronic acid, polyglutamic acid, chitosan and polylysine.
  • ***, the cross-linking agent is calcium salt; when the biomacromolecules are hyaluronic acid or polyglutamic acid, the cross-linking agent is adipic dihydrazide;and when the biomacromolecules are chitosan or polylysine, the cross-linking agent is genipin.
  • ***
  • ***,4-dihydroxyphenylpropionic acid.
  • ***, hyaluronic acid or polyglutamic acid, the compound containing the catechol groups is dopamine; and when the biomacromolecules are chitosan or polylysine, the compound containing the catechol groups is 3,4-dihydroxyphenylpropionic acid.
  • ***-1:5.
  • ***-60%.
  • ***-560 nm.
  • ***-91%.
  • ***, being prepared and obtained with the preparation method according to claim 10.
成果亮点
团队介绍
成果资料